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Chapter 3 Antigen Recognition by B-cell and T-cell Receptors
MHC Proteins Review MHC proteins are encoded in a large gene cluster (locus) called MHC There are lots of MHC genetic variations in a species/population (not in the individual) Individuals express several different MHC type (e.g., 6 classical MHC class I)
T cells, using their TCRs recognize unique structures that result from the combination of the foreign peptide and variable parts of MHC (not peptide, not MHC, but peptide MHC)
Immunoglobulins (Ig) (antibodies, BCRs) are for antigen recognition and destruction
Two main functions for Igs1. Bind antigens recognition (targeting)2. Recruit cells or molecules for destruction of the antigens (effector function)(which effector function does not rely on 2)
TCR has many structural similarities to Igs but it is distinct.
Immunoglobulins (i.e., antibodies)
Constant regions(c regions)
Variable regions(v regions)
Antibodies with different sp
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