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* Countless cycles of replication and death have occurred and the criterion for survival is the passage of DNA despite the challenges:
* 1. number of proteins per cell
* 2. salinity and pH
* 3. Temperature
* 4. nutrient level
* 5. environmental factors
Cell Biology Core
* Cell Functions: Systems Bioengineering
* Cells optimize functions for efficiency and robustness, similar to optimization of industrial production
* Functions can be dissected into steps performed by modules
* Modules contain many proteins and communicate with other modules
* Quantitative measures of function are important: death vs. life is far from full story
* Control theory approaches are useful
* Compartmentalization and term limits correlate robustness
Protein Concentration in Cytoplasm ~180 mg/ml (average protein is 50 kDa, the 3.2 mM protein or 2 x10
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