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PPT : Intraperitoneal therapy in ovarian cancer

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Theory of IP approach
* High IP concentration of drug
* Longer half-life of drug in abdominal cavity than with IV administration
* Prolonged systemic exposure
* Dedrick R et al, Cancer Treat Rep 1978

Clinical settings evaluated
* Intraoperative at time of primary or secondary surgery (+/- hyperthermia)
* Post-operative in advanced disease
o Optimally & suboptimally debulked
* Adjuvant for early-stage disease
* Consolidation
* After neo-adjuvant chemo + surgery

Potential IP approaches
* Standard chemotherapeutic agents
* Radioactive agents (e.g, P32, AU198)
* Immunologic agents
o Radio-labeled antibodies
o Cytokines (interferon, etc)
o Tumor-infiltrating lymphocytes

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PPT : Intraperitoneal therapy in ovarian cancer Category : Cancer
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