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PPT : Lung Immunology Group – Molecular immunology of lung disease

Regulation of immunity in bronchiectasis and ABPA
Bronchiectasis
* Irreversible, abnormal dilatation of one or more bronchi, with chronic airway inflammation. Associated chronic cough, sputum production, recurrent chest infections, airflow obstruction, and malaise
* Prevalence unknown (not common)
* Pathological endpoint with many underlying causes

Pathogens associated with exacerbations and disease progression in bronchiectasis
Haemophilus influenzae
Haemophilus parainfluenzae
Pseudomonas aeruginosa
Streptococcus pneumoniae
Moraxella catarrhalis
Staphylocccus aureus
Stenotrophomonas maltophilia

Gram-negative enterobacter
* Non-tuberculosis mycobacteria
o M. avium complex (MAC)
o M. kansasii
o M. chelonae
o M. fortuitum
o M. malmoense
o M. xenopi
* Aspergillus-related disease

Causes and associations of bronchiectasis
Papworth (n=150) Brompton (n=165)
* Idiopathic5326
* Postinfectious2934
* Humoral immunodeficiency 87
* Allergic bronchopulmonary aspergillosis (ABPA) 78
* Aspiration/GI reflux 41
* Rheumatoid arthritis 32
* Youngs Syndrome 33
* Cystic Fibrosis31
* Ciliary dysfunction 1.510
* Ulcerative colitis<13
* Panbronchiolitis<12
* Congenital<1-
* Yellow nail stndrome -2

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