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PPT : Molecular Basis Of Cancer

Cellular Basis of Cancer
* Cancer is a collection of diseases characterized by abnormal and uncontrolled growth
* Cancer arises from a loss of normal growth control
* In normal tissues, the rates of new cell growth and old cell death are kept in balance
* In cancer, this balance is disrupted
* This disruption can result from

1) uncontrolled cell growth or
2) loss of a cell’s ability to undergo apoptosis

Cancer Cell Do Not Grow Faster Than
Normal Cells
Rather, Their Growth is Just
Uncontrolled
1 fertilized egg
50×1012
Proliferation
Differentiation
Death
1016 cell divisions/lifetime
Proliferation
Differentiation
Death
Transit
Proliferating
Exiting
Renewing
Cellular equilibrium

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