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PPT : Nicotine Dependence and Smoking Behaviour A Genetic and Epidemiological Study

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The worldwide health burden caused by the tobacco epidemic highlights the importance of study-ing determinants of smoking behaviour and key factors sustaining nicotine dependence. Despitevast-ranging preventive efforts, smoking remains one of the most deleterious health behaviours, andits genetic and environmental factors warrant continuous investigation. The heritability of smokingbehaviour and nicotine dependence has been suggested to be relatively high. Earlier smoking behav-iour, nicotine dependence, socio-economic position and demographic factors have all been shownto be associated with smoking cessation. This thesis aimed to examine various aspects of smokingbehaviour and nicotine dependence from an epidemiological and genetic perspective.Data for Studies I and IV were obtained from the Older Finnish Twin Cohort, a postal health surveyconducted in 1975, 1981 and 1990 on same-sexed pairs and in 1996-1997 on male-female adultpairs. The number of ever-smoking participants was 8941 in Study I and 3069 in Study IV. Datafor Studies II and III came from the Family Study of Cigarette Smoking – Vulnerability to NicotineAddiction. This study is linked to the Older Finnish Twin Cohort with new data collection during2001-2006 that focused on smoking twin pairs and their family members. The measures includedintensive telephone interviews, blood samples and additional postal questionnaires. The numbers ofever-smoking participants was 1370 in Study II and 529 in Study III.

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PPT : Nicotine Dependence and Smoking Behaviour A Genetic and Epidemiological Study Category : Addictions
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