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PPT : Sterilization, disinfection and antisepsis

In 1866 J lister suggested antiseptic surgery. His rational was (????????) :
* Putrefaction is caused by microbes
* Wound sepsis is a form of putrefaction
* Wound sepsis is caused by microbes
* In the previous year Lister had heard that ‘carbolic acid’ was being used to treat sewage in Carlise, and that fields treated with the affluent were freed of a parasite causing disease in cattle.
* Lister then began to clean wounds and dress them using a solution of carbolic acid. He was able to announce at a British Medical Association meeting, in 1867, that his wards at the Glasgow Royal Infirmary had remained clear of sepsis for nine months.
* Opposition was great In England and the United States mainly against Lister’s germ theory rather than against his “carbolic treatment.”

Phenols and phenolics
* Carbolic acid
* Low level disinfetanct
* O-phenylphenol (Lysol)
* Hexachlorophene (Phisohex)
o High level for Staphylococcus sp. and Streptococcus sp.
o Surgical scrubs
* Damage membrane, inactive enzymes, denature proteins

The day after SARS
* Ethylene oxide: denatures proteins
* Highly penetrating
* Most used in hospitals for plastic ware, textiles, etc…..

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Sterilization ppt

Tags: antiseptic surgery, ethylene oxide, glasgow royal infirmary

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